Nrf2 Activator IV activates Nrf2 in the body. Users of Nrf2 activators report positive experiences.
RESEARCH ARTICLE (from pubmed.gov):
J Med Chem. 2014 Feb 27;57(4):1473-87. doi: 10.1021/jm401788m. Epub 2014 Feb 5.
Discovery of vinyl sulfones as a novel class of neuroprotective agents toward Parkinson's disease therapy.
Although the etiology of Parkinson's disease (PD) remains elusive, recent studies suggest that oxidative stress contributes to the cascade leading to dopaminergic (DAergic) neurodegeneration. The Nrf2 signaling is the main pathway responsible for cellular defense system against oxidative stress. Nrf2 is a transcription factor that regulates environmental stress response by inducing expression of antioxidant enzyme genes. We have synthesized novel vinyl sulfone derivatives. They exhibited a broad range of activities in inducing HO-1, whose gene expression is under the control of Nrf2. Among them, compound 12g was confirmed to activate Nrf2 and induce expression of the Nrf2-dependent antioxidant enzymes NQO1, GCLC, GLCM, and HO-1, at both mRNA and protein levels in DAergic neuronal cells. This was accompanied by protection of DAergic neurons in both in vitro and MPTP-induced in vivo models of PD. In addition, compound 12g effectively resulted in attenuation of the PD-associated behavioral deficits in the mouse model.
PMID: 24467268 [PubMed - indexed for MEDLINE]
[INTERPRETATION: Oxidative stress causes the nerve destruction resulting in Parkinson’s. Nrf2 is the main defense against this oxidative stress by causing antioxidants to fight it. Compound 12g (Nrf2 Activator IV) activates Nrf2, activating body-made antioxidants to protect the neurons. It has been proven to be effective in reducing the symptoms of Parkinson’s.]