People who have Intestinal Problems report that their symptoms have decreased after taking an Nrf2 activator. Following the testimonials are current research articles that report new information about the cause of Intestinal Problems and how Nrf2 activators can be effective in treating them at the cellular level where they start.
Frank Naquin: "Eight years ago I was diagnosed with aggressive Prostate Cancer. It was already in stage 4, and I needed surgery immediately. After the surgery I went home. In a couple of weeks my appendix ruptured. I had to have an appendectomy, and they left my abdomen open for 3 weeks. I went home, and the following day I had a heart attack. I had to go back in the hospital, and they put a stent in my heart. A couple of weeks after that they had to do some work on my right leg muscle because of problems they had with the appendectomy. After the surgery they did a colonoscopy, and I was diagnosed with colon cancer. They removed my entire colon. I got a staff infection and stayed in the hospital two and a half months. I went home with a colostomy, and that didn't work. It wouldn't stay attached. So they came up with an experimental procedure called a j-pouch. They use your intestine to make an internal pouch. They failed to tell me that I would have diarrhea the rest of my life. On good days I would go 8 to 14 times a day. On bad days it could be 15 to 30 times a day. I had 20 bad days a month and 10 good days. In order to try to control the diarrhea they put me on steroids and codeine. As your body acclimates itself to the drugs they had to continue to raise the dosage. It really never worked. After 6 months they put me on a chemo drug to control the diarrhea and to keep the bacteria out and to keep cancer from that pouch. I stayed on the chemo drug for six and a half years....
I couldn't eat any decent food without having heavy abdominal pains and heavy diarrhea. I didn't sleep more than an hour or so a night at one time before having to go to the bathroom. There was no quality of life whatsoever. I was about at the end of my rope, and they were going to remove the internal pouch and go back with the colostomy which is something I didn't want.
"Then someone brought me a DVD showing the effects of Protandim. I had never heard of it, and I really didn't want to take another pill, but after a couple of weeks of that DVD sitting in my kitchen I decided to watch the video. Once I watched it I researched more on the computer and I decided that night I was going to take it. The next day I called a distributor, ordered a bottle, and he gave me some to take while my order came in. I started taking Protandim the beginning of April, and within two weeks the abdominal pain ceased. I had no more abdominal pain. The diarrhea was cut more than half. I started backing off the steroids and codeine pills. Within three weeks I was completely off the steroids and codeine, and I had no abdominal pain, no diarrhea and no chest pains." youtube.com, search "Protandim"
RESEARCH ARTICLE (from pubmed.gov):
PLoS Genet. 2014 Aug 28;10(8):e1004568. doi: 10.1371/journal.pgen.1004568. eCollection 2014.Integration of UPRER and oxidative stress signaling in the control of intestinal stem cell proliferation.
The Unfolded Protein Response of the endoplasmic reticulum (UPRER) controls proteostasis by adjusting the protein folding capacity of the ER to environmental and cell-intrinsic conditions. In metazoans, loss of proteostasis results in degenerative and proliferative diseases and cancers. The cellular and molecular mechanisms causing these phenotypes remain poorly understood. Here we show that the UPRER is a critical regulator of intestinal stem cell (ISC) quiescence in Drosophila melanogaster. We find that ISCs require activation of the UPRER for regenerative responses, but that a tissue-wide increase in ER stress triggers ISC hyperproliferation and epithelial dysplasia in aging animals. These effects are mediated by ISC-specific redox signaling through Jun-N-terminal Kinase (JNK) and the transcription factor CncC. Our results identify a signaling network of proteostatic and oxidative stress responses that regulates ISC function and regenerative homeostasis in the intestinal epithelium.
PMID: 25166757 [PubMed - indexed for MEDLINE] PMCID: PMC4148219
[INTERPRETATION: Imbalance within cells causes diseases and cancers in the intestinal system. The imbalance is caused by oxidative stress (cell damage by oxidants), but can be controlled by proteins that bring back balance (homeostasis) to the intestinal cells.]