People who have Fibromyalgia report that their symptoms have decreased after taking an Nrf2 activator. Following the testimonials are current research articles that report new information about the cause of Fibromyalgia and how Nrf2 activators can be effective in treating it at the cellular level where it starts.
RESEARCH ARTICLE (from pubmed.gov):
Redox Rep. 2014 Jul;19(4):148-53. doi: 10.1179/1351000213Y.0000000079. Epub 2014 Jan 3.Serum prolidase enzyme activity and oxidative status in patients with fibromyalgia. Abstract OBJECTIVE:
This study was performed to investigate serum prolidase enzyme activity and oxidative stress in patients diagnosed with fibromyalgia (FM).METHODS:
The study population consisted of 40 patients with a previous diagnosis of FM and 30 healthy subjects. We measured serum prolidase enzyme activity, total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (OSI), and paraoxonase-1 (PON-1) levels.RESULTS:
On average, FM patients were diagnosed within 3.2 years of symptom onset, and patients had a mean of 14 tender points. There were no significant differences between patients and controls in age, body mass index, serum TAS, or PON-1 levels. However, patients with FM demonstrated higher serum prolidase activity, TOS, and OSI than the control group. Serum prolidase activity was positively correlated with serum TOS, OSI, and visual analog scale pain and fatigue scores. No correlation was found between serum prolidase activity and FM duration or the average number of tender points.DISCUSSION:
Our results demonstrate a previously unreported association between serum prolidase enzyme activity and FM. Increased prolidase activity may contribute to the pathogenesis of FM, and measuring serum prolidase enzyme activity may be a useful FM biomarker.
PMID: 24620938 [PubMed - indexed for MEDLINE]
[INTERPRETATION: People who suffer with Fibromyalgia have higher oxidation levels and higher oxidative stress (cell damage from free radicals). Oxidative stress is directly correlated to prolidase, which is at least partly the cause of Fibromyalgia. APPLICATION: Nrf2 activators cause the body to produce more antioxidants, which then reduce the cell damage and other causes of Fibromyalgia.]
RESEARCH ARTICLE (from pubmed.gov):
Eur Rev Med Pharmacol Sci. 2014;18(8):1199-203.
Evaluation of some antioxidant enzyme activities (SOD and GPX) and their polymorphisms (MnSOD2 Ala9Val, GPX1 Pro198Leu) in fibromyalgia.
Fibromyalgia syndrome (FMS) is a pain syndrome in which common pain in muscle-skeletal system, sleeping disorder and fatigue symptoms coexist. The aim of the present study was to determine SOD and GPX enzyme levels in FMS as well as to investigate possible associations between FMS and Ala9Val polymorphism of MnSOD2 and Pro198Leu polymorphism of GPX1.
PATIENTS AND METHODS:
The study included 127 women FMS patients and 56 healthy subjects. Total SOD and total GPX enzyme activities were determined in patient and control groups. In addition, frequencies of Ala9Val polymorphism of MnSOD2 and Pro198Leu polymorphism of GPX1 were also detected.
SOD enzyme activity was higher in FMS group compared to control (p < 0.001). GPX enzyme activity, on the other hand, was not different between FMS and control groups. No significant differences were found between genotype and allele frequencies of GPX1 and MnSOD2 polymorphisms.
Elevated total SOD and unchanging total GPX1 activities in FMS patients could be the reason for increased oxidative stress and lipid peroxidation in FMS. Genotype and allele frequencies of Ala9Val polymorphism of MnSOD2 and Pro198Leu polymorphism of GPX1 in FMS have been studied first time in the present study, and no associations were found between them and FMS.
PMID: 24817295 [PubMed - in process] Free full text
[INTERPRETATION: In patients with Fibromyalgia, it was found that Superoxide Dismutase (SOD) was higher than in healthy people, but that the body-made antioxidant Glutathione (GPX) was at the same level. This could be the reason for increased oxidative stress (cell damage by free radicals). The assumption is that if glutathione levels were higher, then the oxidative stress would decrease and thus so would the Fibromyalgia.]