TAT 14 is an Nrf2 activator. Users of Nrf2 activators report positive experiences.
RESEARCH ARTICLE (from pubmed.gov)
ACS Med Chem Lett. 2012 May 10;3(5):407-410. Epub 2012 Mar 12.
Anti-inflammatory Effect of a Cell-Penetrating Peptide Targeting the Nrf2/Keap1 Interaction.
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is increasingly recognized as a central regulator of multiple signaling pathways in inflammation and cancer, and the ability to use chemical biological tools to investigate its biological effects is very attractive. A peptide comprising a TAT-conjugated Nrf2 sequence is shown to activate Nrf2 and its downstream target gene heme-oxygenase-1 (HO-1) in a dose-dependent manner in intact human THP-1 monocytes. Levels of Nrf2 protein peak after 3 h, whereas HO-1 mRNA and protein peak after 6 and 12 h, respectively. The peptide is also shown to inhibit the production of the pro-inflammatory cytokine TNF. The TAT-14mer constitutes a useful chemical biology tool with potential therapeutic applications.
PMID: 22582137 [PubMed] PMCID: PMC3350226 Free PMC Article
[INTERPRETATION: Nrf2 regulates many aspects of swelling and cancer. TAT-14 activates Nrf2, which stops inflammation. It can be used for therapy for cancer and inflammation.]