TAT 14 Testimonials and Science

TAT 14 is an Nrf2 activator.  Users of Nrf2 activators report positive experiences.

However, no testimonials or product reviews were found for this particular drug.



RESEARCH ARTICLE (from pubmed.gov)

ACS Med Chem Lett. 2012 May 10;3(5):407-410. Epub 2012 Mar 12.

Anti-inflammatory Effect of a Cell-Penetrating Peptide Targeting the Nrf2/Keap1 Interaction.

Abstract

Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is increasingly recognized as a central regulator of multiple signaling pathways in inflammation and cancer, and the ability to use chemical biological tools to investigate its biological effects is very attractive. A peptide comprising a TAT-conjugated Nrf2 sequence is shown to activate Nrf2 and its downstream target gene heme-oxygenase-1 (HO-1) in a dose-dependent manner in intact human THP-1 monocytes. Levels of Nrf2 protein peak after 3 h, whereas HO-1 mRNA and protein peak after 6 and 12 h, respectively. The peptide is also shown to inhibit the production of the pro-inflammatory cytokine TNF. The TAT-14mer constitutes a useful chemical biology tool with potential therapeutic applications.

PMID:  22582137  [PubMed]    PMCID:  PMC3350226  Free PMC Article

[INTERPRETATION:  Nrf2 regulates many aspects of swelling and cancer.  TAT-14 activates Nrf2, which stops inflammation.  It can be used for therapy for cancer and inflammation.]