Stroke

People who have had a Stroke report that their symptoms have decreased after taking an Nrf2 activator.  Following the testimonials are current research articles that report new information about the cause of Stroke and how Nrf2 activators can be effective in preventing it at the cellular level where it starts, and treat the Stroke after it has happened.

Wilson V.:  My dad was taking 17 medications a day.  So my friend asked if I was open to trying something natural that she heard was working so well that many people were getting off of prescription medications.  I said absolutely.  What can it hurt at this point.  For the last 4 years Dad's doctor had been increasing his prescriptions due to all the side effects of each pill he was prescribing.  He started off with 6 and it went up from there.  
     If you listen to the pharmaceutical commercials they list some horrific side effects, but the doctors will always say that the positive outweighs the negative. There's only so much that our kidneys [or livers] can take but that doesn't seem to be our doctor's concern as he kept increasing Dad's medications.  I recall how tired he was and lacked energy.  I just kept believing that he was someday going to pull out of this condition since his stroke in May 2008. 
     Of course, I was open to trying a more natural approach. So Dad starting taking Protandim on August 27, 2012 faithfully, along with all 17 meds a day.  Six weeks later on October 8, 2012, my Dad went in for his routine check-up at the world-renowned Mayo Clinic.  After running many comprehensive tests, including blood work and x-rays, the doctors could not find anything wrong with him like they had before.  In fact, they said his lab results went so well that the doctor took him off of 14 of his 17 medications!  They couldn't believe it.   youtube.com, search "Protandim"

Dr. Nathan Bailey.  Dr. Bailey had  a stroke affecting his whole right side.  This problem affected his career and his family.  He suffered with his symptoms for two years before he started taking Protandim.  Without doing anything else different than taking the Protandim, he woke up one morning 6 months later symptom-free.  Watch him tell his own story at https://www.youtube.com/watch?v=yFY3PyKG48w
Linda Dietz:  My brother in law who is 75 and recently had some physical problems, got a strong tremorof his right hand-,--he started Vivix, his only Shaklee product-and within a few days his tremor is gone and he is writing normally again! He is duly impressed and thankful.    Go to source.
Stroke Victim: A massive stroke 3 1/2 years ago (doctors attribute to my irregular heartbeat-- I believe it was stress) attacked my right brain (and basil ganglia) leaving my left side totally unavailable and the right brain majorly stressed, reactive, and depressed. Never totally giving up, taking handfuls of Shaklee supplements, exercising, listening to motivational cd's, getting Brain Gym balances, regular chiropractic care, etc., my progress was evident to those who knew me, including my doctors. But what they didn't see was the exhaustion and struggle it took. Then along came Vivix, August 15, less than 6 weeks ago. First I thought it was probably the placebo effect, but today I can tell you a few of the things I KNOW have changed:
BALANCE--so bad in the past that one of the many falls landed me under my rolling car, crushing my right leg, though not the bone. My balance has improved so much I now climb stairs, carrying some thing in EACH hand, and not even holding onto the rail.
ENERGY--so different now I can do 30 minutes on the treadmill, noting my improved heart rate & instead of having to take a nap, I take off to do errands, deliver Shaklee and attend a Spanish Class in which I am much more focused.
FOCUS-Always had ADD and hypoglycemia; worse since numerous car wrecks in the 80's and the more recent stroke. I am experiencing now more blood sugar balance and longer attention spans--just finished reading a whole book in a couple of days and, most assuredly, I am making an A in the Spanish class (where my classmates & teacher are @ 1/3 my age).So I would say my mental acuity and memory are enhanced as well!
ATTITUDE--OH MY GOSH! I woke up this morning, like most others since starting on this magical stuff, full of vitality & optimism, and HAPPY.
LIFE IS GOOD! Thank you Shaklee! I have my life back, better than ever!   Go to source.

Wilson V.:     My sister who takes care of my Dad wrote this email to me:  "I was first introduced to this product when I had expressed to my friend my frustration over the cost of pharmaceutical drugs over a year ago.  I had just picked up 3 refills and was informed that Dad had maxed his Medicare prescription coverage of approximately $3,000 and therefore he was now in the "gap" coverage which meant higher expense for his meds.  It cost more than $100 to pick up 3 meds that day.  It  was only August so there were still 4 more months before his coverage would renew at the start of the next year.  
     He was taking 17 medications a day.  So my friend asked if I was open to trying something natural that she heard was working so well that many people were getting off of prescription medications.  I said absolutely.  What can it hurt at this point.  For the last 4 years Dad's doctor had been increasing his prescriptions due to all the side effects of each pill he was prescribing.  He started off with 6 and it went up from there.  
     If you listen to the pharmaceutical commercials they list some horrific side effects, but the doctors will always say that the positive outweighs the negative. There's only so much that our kidneys [or livers] can take but that doesn't seem to be our doctor's concern as he kept increasing Dad's medications.  I recall how tired he was and lacked energy.  I just kept believing that he was someday going to pull out of this condition since his stroke in May 2008
     Of course, I was open to trying a more natural approach. So Dad starting taking Protandim on August 27, 2012 faithfully, along with all 17 meds a day.  Six weeks later on October 8, 2012, my Dad went in for his routine check-up at the world-renowned Mayo Clinic.  After running many comprehensive tests, including blood work and x-rays, the doctors could not find anything wrong with him like they had before.  In fact, they said his lab results went so well that the doctor took him off of 14 of his 17 medications!  They couldn't believe it.  
     Dad continued to see his family physician while taking the usual quarterly blood work.  By January he no longer needed insulin, because of his taking Protandim.  That was, to me the best news as I hated to poke him four times a day [with a needle]. Dad was always such a trooper throughout this process. So as of August 2013, we got his Medicare coverage statements and Dad is nowhere close to the expenses he incurred last August -- thanks to the Lord who introduced this natural, God given product to us..."  
     Update October 2013: My Dad is now taking only 3 medications a day instead of 17, due to Protandim.  

My sister's email continues: "...Now our whole family is taking it.  I just turned 50 and I have enough energyto take care of Dad while taking care of myself.  I do 5 days of high-intensity Zumba classes, take a 90 minute tennis clinic (drills) in the heat of the day and play tennis again for another 2 hours during the week and then take a self-defense class twice a week.  And no, I do not have to ice my knees or crawl out of bed!  In fact, my husband and girls can attest to the fact that I can go on as little as 5-6 hours of sleep.  God is SOOO good! I just want to share this product and opportunity with everyone so they too can enjoy the life they're given because 80 is TRULY the new 20!"  (http://www.aliveandyoung.com/testimonials.html)

RESEARCH ARTICLE (from pubmed.gov)
Int J Neurosci. 2015 May 22:1-28. [Epub ahead of print]
Remote limb ischemic postconditioning protects mouse brain against cerebral ischemia/reperfusion injury via upregulating expression of Nrf2, HO-1, NQO-1 in mice.
Abstract

Remote ischemic postconditioning (RIPostC) is a promising therapeutic intervention, which has been discovered to reduce ischemia/reperfusion (I/R) injury in heart, kidney, brain and skeletal muscle experimentally. However, its potential protective mechanisms have not been well elucidated. The aim of this study was to investigate the protective effect of RIPostC in cerebral I/R injury and explore the new putative mechanisms of neuroprotection elicited by it. Focal cerebral ischemia was induced by transient middle cerebral artery occlusion (tMCAO) in male CD1 mice. RIPostC was generated by three cycles of 5 minute reperfusion/5 minute occlusion of the bilateral femoral artery on the bilateral limbs at the onset of middle cerebral artery reperfusion. RIPostC significantly improved neurological outcome, lessened infarct volume and brain edema, up-regulated the expression of Nrf2, HO-1, NQO-1 and activity of SOD, down-regulaed the formation of MDA ( P < 0.05). Taken together, these findings demonstrated that RIPostC protected the brain from I/R injury after focal cerebral ischemia by reducing oxidative stress and activating of the Nrf2-ARE pathway.

PMID: 26000916 [PubMed - as supplied by publisher]


RESEARCH ARTICLE (from pubmed.gov)

 Biomed Res Int. 2015;2015:323706. doi: 10.1155/2015/323706. Epub 2015 Jan 14. Tetrahydrocannabinol induces brain mitochondrial respiratory chain dysfunction and increases oxidative stress: a potential mechanism involved in cannabis-related stroke.

Abstract

Cannabis has potential therapeutic use but tetrahydrocannabinol (THC), its main psychoactive component, appears as a risk factor for ischemic stroke in young adults. We therefore evaluate the effects of THC on brain mitochondrial function and oxidative stress, key factors involved in stroke. Maximal oxidative capacities V max (complexes I, III, and IV activities), V succ (complexes II, III, and IV activities), V tmpd (complex IV activity), together with mitochondrial coupling (V max/V 0), were determined in control conditions and after exposure to THC in isolated mitochondria extracted from rat brain, using differential centrifugations. Oxidative stress was also assessed through hydrogen peroxide (H2O2) production, measured with Amplex Red. THC significantly decreased V max (-71%; P < 0.0001), V succ (-65%; P < 0.0001), and V tmpd (-3.5%; P < 0.001). Mitochondrial coupling (V max/V 0) was also significantly decreased after THC exposure (1.8±0.2 versus 6.3±0.7; P < 0.001). Furthermore, THC significantly enhanced H2O2 production by cerebral mitochondria (+171%; P < 0.05) and mitochondrial free radical leak was increased from 0.01±0.01 to 0.10±0.01% (P < 0.001). Thus, THC increases oxidative stress and induces cerebral mitochondrial dysfunction. This mechanism may be involved in young cannabis users who develop ischemic stroke since THC might increase patient's vulnerability to stroke.

PMID: 25654095   [PubMed - in process]   PMCID:  PMC4310259   Free PMC Article

[INTERPRETATION:  A substance that increases oxidative stress (cell damage) also damages the energy production mechanism and causes stoke.] 

RESEARCH ARTICLE (from pubmed.gov): 

Front Cell Neurosci. 2015 Jan 20;8:457. doi: 10.3389/fncel.2014.00457. eCollection 2014.

Ginseng: a promising neuroprotective strategy in stroke.

Abstract

Ginseng is one of the most widely used herbal medicines in the world. It has been used in the treatment of various ailments and to boost immunity for centuries; especially in Asian countries. The most common ginseng variant in traditional herbal medicine is ginseng, which is made from the peeled and dried root of Panax Ginseng. Ginseng has been suggested as an effective treatment for a vast array of neurological disorders, including stroke and other acute and chronic neurodegenerative disorders. Ginseng's neuroprotective effects are focused on the maintenance of homeostasis. This review involves a comprehensive literature search that highlights aspects of ginseng's putative neuroprotective effectiveness, focusing on stroke. Attenuation of inflammation through inhibition of various proinflammatory mediators, along with suppression of oxidative stress by various mechanisms, including activation of the cytoprotective transcriptional factor Nrf2, which results in decrease in reactive oxygen species, could account for its neuroprotective efficacy. It can also prevent neuronal death as a result of stroke, thus decreasing anatomical and functional stroke damage. Although there are diverse studies that have investigated the mechanisms involved in the efficacy of ginseng in treating disorders, there is still much that needs to be clarified. Both in vitro and in vivo studies including randomized controlled clinical trials are necessary to develop in-depth knowledge of ginseng and its practical applications.

PMID:  25653588    [PubMed]   PMCID:  PMC4299449  Free PMC Article

[INTERPRETATION:  Ginseng maintains homeostasis (system balance) by reducing swelling and oxidative stress (cell damage).  It is efficient because it activates Nrf2, resulting in fewer free radicals and thus protection of nerves.]


RESEARCH ARTICLE (from pubmed.gov):See comment in PubMed Commons below

Curr Med Chem. 2015 Feb 9. [Epub ahead of print]

NAD+/NADH Metabolism and NAD+-Dependent Enzymes in Cell Death and Ischemic Brain Injury: Current Advances and Therapeutic Implications.

Abstract

NAD+ and NADH play crucial roles in a variety of biological processes including energy metabolism, mitochondrial functions, and gene expression. Multiple studies have indicated that NAD+ administration can profoundly decrease oxidative cell death as well as ischemic and traumatic brain injury, suggesting NAD+ metabolism as a promising therapeutic target for cerebral ischemia and head injury. Cumulating evidence has suggested that NAD+ can produce its protective effects by multiple mechanisms, including preventing mitochondrial alterations, enhancing energy metabolism, preventing virtually all forms of cell death including apoptosis, necrosis and autophagy, inhibiting inflammation, directly increasing antioxidation capacity of cells and tissues, and activating SIRT1. Increasing evidence has also suggested that NADH metabolism is a potential therapeutic target for treating several neurological disorders. A number of studies have further indicated that multiple NAD+-dependent enzymes such as sirtuins, polymerase(ADP-ribose) polymerases (PARPs) and CD38 mediate cell death and multiple biological processes. In this article, an overview of the recent findings regarding the roles of NAD+/NADH and NAD+-dependent enzymes in cell death and ischemic brain injury is provided. These findings have collectively indicated that NAD+/NADH and NAD+-dependent enzymes play fundamental roles in oxidative stress-induced cell death and ischemic brain injury, which may become promising therapeutic targets for brain ischemia and multiple other neurological disorders.

PMID: 25666794  [PubMed - as supplied by publisher]

[INTERPRETATION:  the coenzyme NAD+ causes the body’s own-made antioxidants to work better to prevent all forms of cell death and inhibit swelling.  This is promising for future therapy  of stroke and other nervous system problems.]