Skin Problems (eczema, psoriasis, etc.)

People who have Skin Problems report that their symptoms have decreased after taking an Nrf2 activator.  Following the testimonials are current research articles that report new information about the cause of Skin Problems and how Nrf2 activators can be effective in treating them at the cellular level where they start.


Michelle:  "I have suffered from severe Eczema for about thirty years. I have been an Eczema sufferer since I was 7 or 8 years old. I've had Eczema on my hands. I've had difficulty holding a pencil, holding a pen, writing, washing my hands, you name it. Those of you who are Eczema sufferers know what I'm talking about. It's very painful, it's very uncomfortable, and it's quite embarrassing. I have had it quite under control in the last ten years through various means, but I do still get flare ups. In the past 20 days of taking Protandim I have experienced the complete disappearance of my Eczema. In the last 3 weeks I've had quite possibly the softest skin on my hands that I've ever had. So I'm right now contributing that to Protandim."   youtube.com, search "Protandim"

Tim Meyer:  "On day 42 (of taking Protandim) I noticed that my skin is softer. The backs of my hands don't have the old age wrinkles like I used to. On day 56 I was driving home late at night and noticed that headlights weren't bothering me. I have pretty bad astigmatism, and that is what my doctor said gave me the problem of seeing stars and halos around headlights at night. Then looking back at the road it was hard to refocus on what was ahead of me. So I didn't drive at night usually. That night the headlights looked clear so it was much easier to drive at night. My vision is clearer, especially at night."   youtube.com
Kathy Norton:   I have severe psoriasis and the only thing that has worked at all has been Shaklee and light treatments. I started Vivix a week ago and the itching has subsided, and the plaques are diminishing. So far so good.    Go to source.
Mary McGaffic:  I can't believe that Vivix. I had a couple of light brown spots that showed up on my face a few months ago and was considering seeing a dermatologist to have them checked. After just 10 days on Vivix I noticed they were gone. Also the couple on my hands are fading fast. But the absolute best testimony I have after three weeks on Vivix is the following: I developed a spur in my big toe four years ago after I stepped wrong and got a hairline crack on the side of my foot. I eventually couldn't move my toe even a fraction. The doctor called it a 'stiff toe' and said it was a spur. He said my only solution was surgery and wearing ugly shoes the rest of my life. The pain was horrific for months. I couldn't even stand a sheet on my toe. As soon as the doctor said "spur" a light bulb went off. I remembered hearing years ago that Shaklee calcium was the only calcium that broke up arthritic spurs while other types may cause them, so I knew I had to increase my Shaklee calcium and alfalfa. Within 3 days the spur was dissolving, but I developed a lump on the bone above my toe which continued to cause me some pain. I eventually could wear one inch heels as long as the shoe wasn't too tight. I had to buy shoes 1/2 size larger because of the sore. That was definitely better than the doctor’s only solution of surgery and 'ugly shoes' but it just wouldn't heal completely. Then "Vivix" came along. I had taken it for 2 1/2 weeks when I noticed the lump was gone and no more soreness. I wore 2" heels this week for the first time in four years and was pain free. I still had some crystallization in my big toe, but I noticed that is completely dissolved now and I can wiggle my toe perfectly and bend it up, which is probably why I can wear the high heels now (the spur and lump are both completely gone). If I really push where the lump was there is still a slight soreness, but I'm sure that will be gone soon. I am so excited. Thank you Shaklee for this unbelievable product. I had no idea it would help with such a problem. I've missed so much not being able to wear heels as I'm short and they just make me feel more feminine, plus I'm pretty tired of the pain. I was just taking the Vivix to become younger, like we all are. Viva Vivix! I also have a friend in Shaklee who said her bunions are gone and herhusband's dark shadows on his face are practically gone. I don't understand how this works so quickly. It's almost scary, but in a good way. I think Shaklee is going to be receiving some truly amazing testimonies as a result of this product. I think we've only touched the tip of the iceberg. I just had to share this with someone.    Go to source.

Shari Root:  I am finally up to my full tsp of Vivix! And I am as glad as ever that I didn't give up. I already mentioned the white coating on my tongue clearing up (there are only a few small bumps now way in the back), and that I had sun damaged skin that was clearing up very noticeably (the dark brown splotches are disappearing and it is not extremely red anymore) --- but, I am also sleeping much better now (amazing about the vivid dreams - wonder why that effect?), and not only do I have more energy than ever, but also a calmness I didn't have before. One thing my best friend noticed, though, before I did, was that my hands were not visibly shaking any more. (I have had essential tremors in both hands since I was 16 and I have one son who already has it! I am 52 now, so it has been pretty bad at times) I can't say it is totally gone - but my right hand especially is markedly improved (my handwriting had gotten extremely sloppy over the years - but, now I can actually write slow again without the writing being all wobbly!) So, that is something I hadn't even expected to happen at all..... (but definitely thrilled about -- I am hoping now that I just started on the full amount it may improve even more). And, since you mentioned the fingernails ......... mine are the healthiest they've been in many years. (They have been thin & 'peeled' easy, which kept them broken and short). They are hard as a rock and no chipping or peeling now! 

As for Vivix itself being the direct cause of all this I can't say for sure, because of having chronic fatiguefrom the early 90's I also did not absorb nutrients well. Now that I am on the Vivix, I think it is doing what Dr. Brouse explained on his teleconference call - and that is how the Vivix sort of causes the body to "recycle" the nutrients to get more out of less (he explained much better than that, I know). Anyway, I think that part of what is happening for me is from the direct result of what Vivix does for our cells - and the other is the Vivix making what I am already taking work better. What matters most is the results everyone is getting (which I am sure is why all the backorder problems!!) Thank you to Shaklee once again for improving our lives so dramatically!    Go to source.

Pat McNeal:  I want to talk about something one of my members experienced when he went on VIVIX. He has had a fairly large, flat mole on his hairy abdomen for years, but because it was covered with hair, it wasn't very noticeable, and apparently had become somewhat "lumpy" without him knowing it. After starting on VIVIX, maybe a couple of weeks later, it became itchy. When he looked at it, it had become red and inflamed for about 1/3 of an inch around it, with a clear, red, linear margin between the inflamed skin and the normal skin. The mole had several lumpy spots on it that he hadn't noticed before, probably because of the hair covering it. When he showed it to me, my first impression was that the mole was perhaps developing cancer and the VIVIX was causing his body to attack it, thus the inflamed, clearly defined ring around it, since cancer often extends out into the surrounding area. Itching is a common symptom of things healing, so that was another indication that something good was probably happening. He thought about having a biopsy, but decided not to at that point, because he wanted to see what the VIVIX would do on its own to heal it and realized that they would probably take the entire spot off for the biopsy, leaving him to always wonder if the VIVIX would have helped his body take care of it by itself. Now (about 6 weeks after starting on VIVIX) it appears that the VIVIX had done just that! The spot has flattened out and is looking kind of dried and shriveled in the center where the lumps were. The inflammation had gone away after about a week, and the itching is gone, too. It looks to me like it will eventually peel off.
While I'm at it, I'd like to mention that I had a couple of small lumps on sun-damaged spots on the back of my hands; one lump was larger than the other and had been there for several years, before the other one developed. I had wondered if it might be thinking about turning into cancer, so I had been keeping an eye on it. It only grew slightly larger over 2-3 years, but in the meantime, another spot next to it also started to become raised, but because it was a couple of years after the first one, it wasn't as pronounced.

Two weeks after starting on VIVIX, the primary lump sloughed off, left a small scab and then healed completely flat. The lump is totally GONE! The second spot, which was barely lumpy at all.   Took about 5 weeks to just kind of peel a layer off, with no scab. There is still an ever so slight, dry covering at the spot, but I'm confident that if I can ever get back on the VIVIX (we've been out and it is backordered), it will totally go away, too.
My point in all of this, is that I truly believe these two situations were at least precancerous, if not early stage cancers. I think VIVIX is going to stimulate the body to cure at least some kinds of cancers, if one doesn't do things to weaken the immune system - such as chemo. VIVIX does great things for the immune system. I know, because I had a bladder infection when I started on the VIVIX. I had been working with supplements to address it, but had only been successful in keeping it from becoming full-blown. When I took the VIVIX, the infection would calm down for a while, but come back again by the next morning. This went on for 3 days, but after that, the infection was gone. The only difference was the VIVIX. It only took 3 days to boost my immune system to where it knocked out the infection. Therefore, I'm well aware of the benefit it has on the immune system, and this, I believe, will be one way it cures cancer; repairing DNA will probably be another.   Go to source.

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Julie Colegrove:  I am 74, always feel good, take the other supplements and added Vivix. My husband soon felt a difference so I was disappointed when I didn't until week 6- then it seemed that I suddenly said "I feel gooder"! After almost three months on Vivix my eyelashes are back, my age bumps are diminishing and I am having folks say I look younger. I know it must be must be "doing something" at the cellular level. What more could I want?    Go to source.
Luanne:  Since I have been using the Vivix my skin is no longer ruddy looking. Nothing has ever taken the redness away, not even enfuselle. However, I have not noticed any improvement with the dark circlesunder my eyes. My mother (age 73) has noticed an increase in her enthusiasm even after 3 days on the Vivix. I have been having Andy (age 16) take it to help him heal better after jaw surgery, which is scheduled for next month, and he has noticed an improvement in his sinus congestion. He stopped taking the Vivix for a couple of days and the sinus congestion came back.    Go to source.
Alice Brown:   I am now an official senior citizen. Prior to September I knew that my balance was way off, guess it's an age thing. Couldn't carry anything downstairs without grasping the railing, went down a path in early Sept. and scared my friend when I almost fell over! Getting out of the recliner trying to get my slippers on without tipping over, it was not a pretty sight. I started Vivix September 9th. My balance is 100% improved, my skin is soft, blemishes on my nose have gone, my age spot on my face is disappearing, scar on my forehead is fading, my back doesn't ache when I turn over in bed! And I love the taste of Vivix. I appreciate the many testimonies that I have read here. If only my gray hair would go back to it's brown color!    Go to source.
RESEARCH ARTICLE (from pubmed.gov):

Acta Derm Venereol. 2017 Mar 30. doi: 10.2340/00015555-2661. [Epub ahead of print]
Advanced Glycation End Products are Increased in the Skin and Blood of Patients with Severe Psoriasis.
Abstract

Psoriasis is frequently associated with metabolic comorbidities. Advanced glycation end products (AGEs) are highly oxidant, biologically active compounds that accumulate in tissues in association with hyperglycaemia, hyperlipidaemia and oxidative stress. This is a cross-sectional case-control study involving 80 patients with mild/severe psoriasis and 80 controls matched for age, sex and body mass index (40 with severe eczema, 40 healthy individuals). Patients and healthy individuals with a smoking habit, diabetes, dyslipidaemia, hypercholesterolaemia, hypertension or who were under systemic treatment were excluded from the study. Skin AGEs were measured in normal-appearing skin by a standard fluorescence technique, and blood AGEs (total AGEs, pentosidine and AGEs receptor) by enzyme-linked immunosorbent assay. Levels of cutaneous AGEs (p < 0.04), serum AGEs (p < 0.03) and pentosidine (p < 0.05) were higher in patients with severe psoriasis. Cutaneous AGEs correlated well with serum AGEs (r = 0.93, p < 0.0001) and with Psoriasis Area and Severity Index score (r = 0.91, p < 0.0001). Receptor levels were lower (p < 0.001) in severe psoriasis, and inversely correlated with disease severity (r = -0.71, p < 0.0002). Patients with severe psoriasis have accumulation of skin and serum AGEs, independent of associated metabolic disorders.  PMID:28358411

[INTERPRETATION:  Psoriasis is caused by high oxidant compounds that gather in the skin, causing oxidative stress and other problems]. 

RESEARCH ARTICLE (from pubmed.gov):

Cell Biochem Funct. 2014 Apr;32(3):268-273.

Antioxidant status in patients with psoriasis.

Cell Biochem Funct. 2014 Oct;32(7):620. Houshang, Nemati, [corrected to Nemati, Houshang]; Reza, Khodarahmi [corrected to Khodarahmi, Reza]; Masoud, Sadeghi [corrected to Sadeghi, Masoud]; Ali, Ebrahimi [corrected to Ebrahimi, Ali]; Mansour, Rezaei [corrected to Rezaei, Mansour].

Abstract

Psoriasis is a chronic inflammatory skin disease with an unknown aetiology that has been associated with abnormal plasma lipid metabolism and oxidative stress. There are controversial results in the previous studies investigating oxidant/antioxidant systems in psoriasis.  The aim of this work was to evaluate the plasma levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), total bilirubin (T. Bili), direct bilirubin (D. Bili), uric acid (UA), apolipoproteins (ApoA1 and ApoB), Lp(a) and activities of paraxonase 1 (PON1) in 100 patients with psoriasis and 100 controls, and to look for a correlation between these parameters in psoriasis.PON1, bilirubin and UA were measured spectrophotometrically, MDA by the high-performance liquid chromatography method, apolipoproteins and Lp(a) by immunoprecipitation assays, and lipid and other biochemical parameters were determined by routine laboratory methods.  In patients with psoriasis, there was a significant decrease in PON1, SOD and CAT activities (P < 0.05) and an increase in MDA levels (P < 0.01). Also, the levels of bilirubin (total and direct) and UA were decreased in patients with psoriasis but were not significant (P > 0.05).These results suggest that psoriasis was in a state of oxidative stress and that the protective effects of high-density lipoprotein against atherosclerosis may be dependent on PON1 activity. Moreover, there is a negative correlation between antioxidant with Lp(a), apoB and MDA levels, suggesting that subjects with higher levels of Lp(a) and apoB and lower levels of antioxidant are more exposed to oxidative damage. These findings may explain in part the reported increase in cardiovascular mortality in psoriasis.

[INTERPRETATION:  Psoriasis is associated with oxidative stress (cell damage).  People with psoriasis have fewer enzymes to fight the oxidative stress, and the damage is worse when the antioxidant levels are lower.]


RESEARCH ARTICLE (from pubmed.gov)
J Clin Diagn Res. 2013 Dec;7(12):2683-5. doi: 10.7860/JCDR/2013/6635.3732. Epub 2013 Dec 15.
Role of reactive oxygen species and antioxidants in atopic dermatitis.
Abstract
BACKGROUND:

In humans, oxidative stress is involved in many diseases such as atherosclerosis, Parkinson's disease, heart failure, myocardial infarction, Alzheimer's disease, Fragile X syndrome and chronic fatigue syndrome. Atopic dermatitis (AD), also known as atopic eczema, is a non-contagious, relapsing inflammatory skin disease which is characterized by eczema and pruritus. The skin reacts abnormally to irritants, food and environmental allergens and it becomes very itchy, which leads to scratching, redness and flaky skin. Very little study has been done to find out the relationship between oxidative stress and Atopic dermatitis.

AIM:

The aim of our work was to evaluate the status of oxidative stress in patients of Atopic dermatitis in comparison with healthy control subjects.

MATERIAL AND METHODS:

Twenty five patients of known Atopic dermatitis and 25 normal healthy controls of same age group were included in the study. Estimations of oxidants like Malondialdehyde (MDA), enzymatic antioxidants like Superoxide dismutase (SOD), Catalase, Glutathione peroxidase (GPX) and non-enzymatic antioxidants like reduced Glutathione (GSH), Vitamin A, Vitamin E and Vitamin C were done to assess the oxidative stress.

RESULTS:

Atopic dermatitis patients were more prone to damage caused by Reactive Oxygen Species (ROS) or Oxidants, than controls, which was evident from an increase of Malondialdehyde and a decrease of enzymatic and non enzymatic Antioxidants.

CONCLUSION:

Antioxidants may possibly be beneficial in the treatment of Atopic dermatitis, which must be substantiated by further studies.

[INTERPRETATION:  Oxidative stress causes the damage seen in eczema.  The body's own antioxidants (SOD, Catalase, and Glutathione) and other antioxidants (vitamins A,E,C) are beneficial in treating eczema.]


RESEARCH ARTICLE (from pubmed.gov): 

Int J Mol Sci. 2013 Apr 26;14(5):9126-67. doi: 10.3390/ijms14059126.

Targeting the redox balance in inflammatory skin conditions.

Abstract

Reactive oxygen species (ROS) can be both beneficial and deleterious. Under normal physiological conditions, ROS production is tightly regulated, and ROS participate in both pathogen defense and cellular signaling. However, insufficient ROS detoxification or ROS overproduction generates oxidative stress, resulting in cellular damageOxidative stress has been linked to various inflammatory diseases. Inflammation is an essential response in the protection against injurious insults and thus important at the onset of wound healing. However, hampered resolution of inflammation can result in a chronic, exaggerated response with additional tissue damage. In the pathogenesis of several inflammatory skin conditions, e.g., sunburn and psoriasis, inflammatory-mediated tissue damage is central. The prolonged release of excess ROS in the skin can aggravate inflammatory injury and promote chronic inflammation. The cellular redox balance is therefore tightly regulated by several (enzymatic) antioxidants and pro-oxidants; however, in case of chronic inflammation, the antioxidant system may be depleted, and prolonged oxidative stress occurs. Due to the central role of ROS in inflammatory pathologies, restoring the redox balance forms an innovative therapeutic target in the development of new strategies for treating inflammatory skin conditions. Nevertheless, the clinical use of antioxidant-related therapies is still in its infancy.

[INTERPRETATION:  Free radicals (ROS) cause long-term inflammation after skin injury, which causes more free radicals, causing even more damage, and depletes the body’s antioxidants, so there is no balance and the inflammation continues.  Antioxidants are a new therapy.]

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