Multiple Sclerosis

People who have MS report that their symptoms have decreased after taking an Nrf2 activator.  Following the testimonials are current research articles that report new information about the cause of MS and how Nrf2 activators can be effective in treating it at the cellular level where it starts.


Lisa:  "I was introduced to Protandim about 7 or 8 weeks ago because I have Multiple Sclerosis. I was on 5 different medications that helped me get through my day with MS. One was Phentermine to keep me awake, plus Ambien to put me to sleep at night, Cymbalta for neuropathic pain, my blood pressure medicine and Tizanidine which is a muscle relaxer. All of these medicines were every day including 3 shots a week for anti-inflammatory reasons. In several weeks time I have weaned myself off of every medication. My energy levels are up, and I'm feeling wonderful, and I am pain free which is the most amazing thing for me. I am a believer. I thought if it could just give me some energy, which is what I expected it to do. I never, ever expected everything else that came with it. Thank you. Thank you very much."  youtube.com, search "Protandim"

Montel Williams:  "I thought I was on top of the world, and then all of a sudden I got diagnosed with MS. I was in Utah to film an episode for a TV show with George Clooney. My legs felt like they were on fire. My shins were on fire, my thighs were on fire, and it wouldn't stop, and that's what sent me into the doctor. The doctor said you have MS. He said you have to stop your talk show, you're going to have to stop all the stress, you have to stop all that working out and you're going to have to stop stop stop. I thought, how dare that doctor tell me what was in my crystal ball.

"I looked into the crystal ball. I almost did what a large percentage of people who have MS do, and that is to take my life. I sat in a closet for about three hours sucking on a gun. I got very, very afraid that my children might find me so I decided to get a little smarter. I walked across the street and there are cabs going around all the time in New York. If a cab hits me, everyone will think it happened as an accident. So of course I'm in Manhattan, New York, I cross the street and throw myself in front of a cab, and I get the only cab driver that's paying attention. He slammed on his brakes, picked me up and helped me across the street. And it was that second that made me realize number one, how dare I live down to someone else's expectations of me. When that hit me, it hit me like a brick. To think that I could not survive this after all the things I've survived that you can't even imagine. How dare that man. And this guy that's helping me across the street talking in my ear about how much he enjoyed my show and I realized right then that I don't care what any doctor says about me. I have MS. Yes. My MS will never have me.

"That day I got on my computer. I got three assistants on the computer. I said I want you to find out anything and everything that has anything to do with MS. I found every doctor that claims to be an expert, and I literally went to meet them all. My lead doctor for MS was nominated for the Nobel Peace Prize. I see doctors from Torrence. I see doctors from John Hopkins. I see doctors from University of San Francisco, and after a while after seeing all these doctors, not that I want to put any of them down, but I'm just hearing about all the same issues I was dealing with.

"So what I decided to do was to start researching. Inflammation is kryptonite, kryptonite for most neurological diseases. I set about finding out about everything and anything I could possibly take to reduce the inflammation in my body. Now this very good friend of mine said look, you're looking at finding out more about something called anti-oxidants. I said really? It reduces the inflammation. I looked at the very first study that came out. I take about 38 pills a day every day. My housekeeper put all of my pills together for me every month. I took Protandim for two and a half years, literally every day. I take a lot of things. I take western medication. I take a holistic program and a hormone replacement program because I feel very strongly that you need to have every single weapon in your quiver you can have to go to war, and Protandim was one of those weapons in that quiver.

"This isn't a double-blind study, this isn't a clinical trial, I'm just going to tell you Montel. About 9 months ago I just didn't start feeling right. Waking up in the morning my legs dragged a little bit more, they hurt me more. Five days go by, and I tried to figure out everything I could to find out what it was that had changed in my life in the last month that was making me feel a little weird. I tried to figure it out. So I finally went to my housekeeper and went, let me figure out what it is about my pills. I was thinking maybe she was just forgetting to put the magnesium or the vitamin D in the bag or something. Something was wrong. I checked the bags, and I realized I hadn't ordered Protandim for three months. OK? Protandim was the only pill that was missing out of my bag, she had stopped putting it in there for 20 days. So if the only thing I changed in my life is Protandim, and that clearly started making me feel worse, and the second I put it back in 8 days later I started feeling like myself, this is a product I'm going to stand behind. This is a product that's about making people feel better."   youtube.com, search "Protandim"

Research Article (from pubmed.gov):

Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(11):74-7.

[Biochemical markers of oxidative stress in different forms and phases of multiple sclerosis].

[Article in Russian]

Abstract OBJECTIVE:

To verify a role of oxidative stress in the pathogenesis of multiple sclerosis (MS) and to develop oxidative stress prognostic criteria of disease course and treatment recommendations.

MATERIAL AND METHODS:

We examined 220 patients with different clinical forms and phases of MS. The lipid and protein free-radical oxidation markers were measured using the following parameters: ketodienes, diene conjugates, malondialdehyde, and Schiff bases. The functioning of the endogenous antioxidant defense system was assessed using y the activity of vitamin E, general and non-protein SH-groups, which represented the nonenzymatic segment of the antioxidant defense system. The enzymatic segment markers were superoxide dismutase, glutathione peroxidase, and glutathione reductase.

RESULTS AND CONCLUSION:

The findings revealed significant differences in the oxidative stress intensity indices in patients with different clinical forms and phases of MS, which made it possible to predict disease progression and prescribe the complex antioxidant treatment in the evidence-based practice.

[INTERPRETATION:  The worse the MS is, the higher the oxidative stress  (cell damage).  Antioxidants can be prescribed as treatment.]


Research Article (from pubmed.gov):

Mult Scler. 2015 Jan 12. pii: 1352458514564590. [Epub ahead of print]

Analysis of genes, pathways and networks involved in disease severity and age at onset in primary-progressive multiple sclerosis.

Abstract 

BACKGROUND:

The role of genetic factors in influencing the clinical expression of multiple sclerosis (MS) is unclear.

OBJECTIVE:

The objective of this paper is to identify genes, pathways and networks implicated in age at onset (AAO) and severity, measured using the Multiple Sclerosis Severity Score (MSSS), of primary-progressive MS (PPMS).

METHODS:

We conducted a genome-wide association study (GWAS) of 470 PPMS patients of Italian origin:. Allelic association of 296,589 SNPs with AAO and MSSS was calculated. Pathway and network analyses were also conducted using different tools.

RESULTS:

No single association signal exceeded genome-wide significance in AAO and MSSS analyses. Nominally associated genes to AAO and MSSS were enriched in both traits for 10 pathways, including: "oxidative phosphorylation" (FDRAAO=9*10-4; FDRMSSS=3.0*10-2), "citrate (TCA) cycle" (FDRAAO=1.6*10-2; FDRMSSS=3.2*10-3), and "B cell receptor signaling" (FDRAAO=3.1*10-2; FDRMSSS=2.2*10-3). In addition, an enrichment of "chemokine signaling pathway" (FDR=9*10-4) for AAO and of "leukocyte transendothelial migration" (FDR=2.4*10-3) for MSSS trait was observed, among others. Network analysis revealed that p53 and CREB1 were central hubs for AAO and MSSS traits, respectively.

CONCLUSIONS:

Despite the fact that no major effect signals emerged in the present GWAS, our data suggest that genetic variants acting in the context of oxidative stress and immune dysfunction could modulate the onset and severity of PPMS.

[INTERPRETATION:  Your genetic make-up combined with oxidative stress (cell damage) and how well your immune system works causes MS and then makes it worse.]